SIBBIL: Navigation, sensorimotor integration brain & body integration lab

The main objectives are:

• The study of innate physiological functions (neuromodulation and peptide secretion) and their effect on the activity of RSN neurons and neurons in contact with cerebrospinal fluid.
• The study of the mechanisms linking cerebrospinal fluid and the formation of the dorsal axis and scolioses
• The development of new strategies for the management of spinal cord injuries (mechanical and inflammatory) is leading to molecular and cellular studies in collaboration with Professor Mousselard.

• Dhanasekar M,  K, Greco M, Lunsford ET,  Carbo-Tano M,  Deleuze C, Moisan L, Mora T, Walczak A, Wyart C#. Noradrenaline prolongs the state of motor arrest via cerebrospinal fluid signaling [2026]. DOI: 10.64898/2026.02.06.704024 [in revision in Nature Neuroscience]
• Lunsford ET, Carbo-Tano M, Wyart C. Whole-body central processing of lateral line inputs encodes flow direction relative to the center-of-mass [2026] PNAS 123:e2515782123. DOI: 10.1073/pnas.2515782123.
• Chen AB, Duque M, Wang VM, Dhanasekar M, Mi X, Rymbek A, Tocquer L, Narayan S, Prober D, Yu G, WYART, C, Engert F, Ahrens MB [2025]. Citations: 49. Norepinephrine changes behavioral state via astroglial purinergic signaling Science 388,769-775. DOI: 10.1126/science.adq5233
• Zakine S, Marty H, Courtin T, Quan F, Pascal-Moussellard H, Brice A, Marie-Hardy L. How is familial idiopathic scoliosis transmitted? Analysis of 26 pedigrees. Orthop Traumatol Surg Res. 2025 Sep;111(5):104229. DOI: 10.1016/j.otsr.2025.104229. PMID: 40097022.
• Jia X, Kumar A, Peysson N, Carbo-Tano M, Fidelin K, Didelot M, Lejeune C, Grosse-Wentrup M, Wyart C#, All-optical investigation reveals a hierarchical organization of vsx2+ reticulospinal neurons coordinating steering and forward locomotion. https://www.researchsquare.com/article/rs-7216842/v1  [in revision in Nature Communications]
• Sridhar, G, Vergassola, M, Marques, J, Orger, M, Costa, A#, Wyart C#. Uncovering multiscale structure in the variability of larval zebrafish navigation [2024]. Citations: 17. PNAS, 121:e2410254121;  DOI: 10.1073/pnas.2410254121.
• Costa AC, Ahamed T, Jordan D, Stephens GJ. A Markovian dynamics for Caenorhabditis elegans behavior across scales. Proc Natl Acad Sci U S A. 2024 Aug 6;121(32):e2318805121. DOI: 10.1073/pnas.2318805121. PMID: 39083417.
• Wyart C#, Carbo-Tano, M, Cantaut-Belarif, Y, Orts-Del’Immagine, A, Böhm, UL [2023]. Citations: 57.Cerebrospinal fluid-contacting neurons: Roles in motion, posture, morphogenesis and host defense. Nature Reviews Neuroscience 24:540-556. DOI: 10.1038/s41583-023-00723-8.
• Carbo-Tano*, M, Lapoix*, M, Jia, X, Thouvenin, O, Pascucci, M, Auclair, F, Quan, FB, Albadri, S, Aguda, V, Farouj, Y, Hillman, EMC, Portugues, R, Del Bene, F, Thiele, TR, Dubuc R#, Wyart C# [2023]. Citations: 55.The mesencephalic locomotor region recruits distributed V2a reticulospinal neurons to drive forward locomotion, Nature Neuroscience 26:1775-1790. DOI: 10.1038/s41593-023-01418-0.
• Prendergast AE, Jim KK, Marnas H, Desban L, Quan FB, Djenoune L, Laghi V, Hocquemiller A, Lunsford ET, Roussel J, Keiser L, Lejeune FX, Dhanasekar M, Bardet PL, Levraud JP, van de Beek D, Vandenbroucke-Grauls CMJE, Wyart C# [2023]. Citations: 31. CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current Biology 33:940-956.e10. DOI: 10.1016/j.cub.2023.01.039.
• Thouvenin, O, Keiser, L, Cantaut-Belarif, Y, Carbo-Tano, M, Verweij, F, Jurisch-Yaksi, N, Bardet, PL, Van Niel, G, Gallaire, F, Wyart C# [2020]. Citations: 86. Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. Elife, 9:e47699. DOI: 10.7554/eLife.47699.
• Sternberg, JR, Prendergast, AE#, Brosse, L, Cantaut-Belarif, Y, Thouvenin, O, Orts-Dell'Immagine, A, Castillo, L, Djenoune, L, Kurisu, S, McDearmid, JR, Bardet, PL, Boccara, C, Okamoto, H, Delmas, P, Wyart C# [2018]. Citations: 167. Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Nature Communications, 9:3804. DOI: 10.1038/s41467-018-06225-x.
• Böhm U*, Prendergast A*, Djenoune L, Nunes Figueiredo S, Gomez J, Stokes C, Kaiser S, Suster M, Kawakami K, Charpentier M, Concordet JP, Rio JP, Del Bene F, Wyart C# [2016]. Citations:  201. CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits. Nature Communications, 7:10866. DOI: 10.1038/ncomms10866.